PHB1 / Anti-Prohibitin-1, mitochondrial antibody
Prohibitins (PHBs) are highly conserved proteins belonging to the large SPFH (stomatin, prohibitin, flotillin and HflKC) superfamily. The PHB family of proteins includes two members, termed prohibitin 1 (PHB1)(AT4G28510) and prohibitin 2 (PHB2)(AT1G03860). Both proteins are highly homologous and interdependent: disruption of one homolog results in the destabilization and rapid degradation of the other. Most genomes contain two PHB genes (for PHB1 and PHB2, respectively).
PhytoAB has antibody PHY1034S, the immunogen is KLH-conjugated synthetic peptide of AtPHB1 derived from Arabidopsis thaliana AT4G28510.
Among 25 analyzed species, the sequence of the synthetic peptide used for immunization is 80-99% homologues with the sequence in Glycine max, Medicago truncatula, Spinacia oleracea, Populus trichocarpa.
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