FBA1/2 plays a key role in glycolysis and gluconeogenesis.

Fructose-bisphosphate aldolase is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). Aldolase can also produce DHAP from other (3S,4R)-ketose 1-phosphates such as fructose 1-phosphate and sedoheptulose 1,7-bisphosphate. Gluconeogenesis and the Calvin cycle, which are anabolic pathways, use the reverse reaction. Glycolysis, a catabolic pathway, uses the forward reaction. Aldolase is divided into two classes by mechanism.

In Arabidopsis thaliana, the FBA family including 8 proteins, from FBA1to FBA8. PhytoAB has PHY0406S - FBA1/2(At4G38970/At2G21330), PHY0156S - FBA6/8(AT2G36460/AT3G52930) and PHY1321S - FBA4/6/8 (AT5G03690/ AT2G36460/AT3G52930) antibodies.

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